What is aromataz enzimi?

Aromatase is an enzyme that plays a critical role in the biosynthesis of estrogen from androgens. It is a member of the cytochrome P450 superfamily and is encoded by the CYP19A1 gene. Aromatase is primarily expressed in the ovary, testis, placenta, adipose tissue, and brain. In females, aromatase is responsible for the production of estrogen from androgens in the ovaries and other peripheral tissues, while in males, it plays a crucial role in the synthesis of estrogen from testosterone in adipose tissue and the brain. Aromatase inhibitors are a class of drugs that are used to treat estrogen receptor-positive breast cancer by inhibiting the activity of aromatase.